Purpose: Polycystic Ovarian Syndrome (PCOS) is a heterogeneous clinical syndrome affecting 8–20% of women in reproductive age. It is an intensely familial and heritable disorder with far–reaching damaging effect on health, emphasizing the need for its early diagnosis. The dermatoglyphic study in PCOS will serve this requisite. The aim was to study the dermatoglyphic pattern of PCOS females and to compare them with that of normal females & normal males. Materials and methods: The dermatoglyphic patterns were analyzed for fingertip patterns, Main Line Formula, Main Line Index, Total Finger Ridge Count, Absolute Finger Ridge Count, Inter digital ridge counts and angles atd, dat & adt. The data were analyzed and compared using chi–square test and independent student t–test. Results: In PCOS females, the Main Line Formula pattern (I) 9,7,5’,4,13, showed a significantly higher occurrence of 13% and a significantly higher c–d ridge count compared to control females. Angle adt was significantly less in PCOS females when compared with both control females and males. With the background of hyperandrogenism in PCOS females, the cases also had significant similarities with control males in various parameters studied. Conclusion: Dermatoglyphic study, being the simplest, cost effective and reliable method to be considered as one among the screening methods for PCOS.