Aim: to study the central corneal thickness and corneal endothelial changes in primary open angle glaucoma (POAG). Material and methods: A total of 70 diagnosed cases of POAG were included in this study. The study was conducted for a period of one year. All the patients were thoroughly worked up, including detailed history, comprehensive ocular and systemic examination. Result: Our study observed that POAG was more common in fifth decade of life, the mean age being 54.88 + 9.39 years. Incidence of POAG was more in males (68.57%) as Compared to females (31.42% ). In this study the mean central corneal thickness(CCT) was found to be 504.87+33.37 qm. This observation was statistically significant (p<0.0001). The mean corneal endothelial cell density was 2295.49+208.90cells/mm2. This observation was statistically highly significant( p<0.0001). Conclusion: POAG is a chronic slowly progressive blinding disease in which thinner Central corneal thickness has a significant association as well as there was a statistically significant reduction in mean endothelial cell density.