Perforation in endodontics was defined as an artificial communication between the supporting tissues of the teeth and root canal of the tooth. The prognosis is poor in case of perforation, and it is not properly managed. Owing to the review of literature, there are descriptions of many materials that have great usage in the treatment of perforation. There are various articles describing the efficacy of one material over other material. The present review aims in describing various materials used for root canal perforation like Biodentine, MTA, Portland cement, Bioaggrregate, Endosequence and New Endodontic Cement.