Objectives: To determine the incidence of contrast induced nephropathy (CIN), and to study the applicability of the Mehran’s Risk Score (MRS) in the prediction of CIN in our population. Patients and Methods: A total of 250 patients (186 males and 64 females) who received non ionic iso osmolar contrast media during PCI were included in the study. CIN was defined as a relative increase of >25% or an absolute increase of >0.5 mg/dl in serum creatinine levels two days post procedure and the MRS used to accurately predict the incidence of CIN in patients belonging to the respective risk group. Results: The overall incidence of CIN was 16% .In univariate analysis: age >75 years, diabeties mellitus, heart failure, hypotension, CKD [creatinine >1.5mg/dl] and increased contrast volume predicted a trend towards risk of CIN whereas anemia, gender and IABP failed to reach statistically significance. As MRS increases, the incidence of CIN increases with 11.25%, 17.24%, 32% and 57.14% for low, intermediate, high and very high risk group respectively. Conclusion– CIN is related with many risk factors, so whenever a patient’s MRS is found to be >10 [preprocedure], lowest dose of contrast should be used by incorporating “maximal allowable contrast (MAC) dose” as a part of pre–procedure contrast ‘Time–Out’ and measures for the prevention of CIN should be taken