Introduction : Laryngoscopy and endotracheal intubation are essential in maintaining the airway in elective surgeries , emergency surgeries and for mechanical ventilation in intensive care unit. Laryngoscopy and endotracheal intubation are powerful stimuli, which can increase a transient but marked sympathetic and sympatho–adrenal activity leading to tachycardia, hypertension and dysrhythmias. The aim of the present study is to compare the efficacy between oral clonidine and oral gabapentin pre–medication in attenuation of pressor response during Laryngoscopy and Endotracheal intubation. Methods : A total of 80 patients aged between 20–50 years of both sexes belonging to American Society of anesthesiologists (ASA) physical status I and II scheduled for general anesthesia were randomized into two groups. Group – G – Received Tab. Gabapentin 800mg, 90 minutes prior to surgery. Group – C– Received Tab.Clonidine 0.3mg, 90 minutes prior to surgery. Baseline heart rate [HR], systolic blood pressure [SBP], diastolic blood pressure [DBP] and rate pressure product [ RPP] were recorded as 0 minute value just before induction. Thereafter heart rate, systolic blood pressure, diastolic blood pressure , mean arterial pressure and rate pressure product were recorded at 1, 3, 5 and 10 minutes after endotracheal intubation. Result: At the Base Line and Induction the mean Heart rate in patients with clonidine group is higher when compared to the Gabapentin group which is statistically significant, after that from intubation onwards there is gradual decrease in Heart rate in the both groups and maintained a similar heart rate till 10 min. P value >0.05 in all the times after intubation. There is no significant difference in the mean SBP and MAP between groups at the Base Line and at Induction, P value is>0.5, and later at all time intervals SBP and MAP are lower in Clonidine group when compared to Gabapentin group. P value is <0.05. There is no significant difference in the mean DBP and RPP between groups at all time. Conclusion:. Oral premedication with clonidine 0.3mg 90 minutes prior to induction of anesthesia is safe and effective compared to oral gabapentin 800mg to attenuate the pressor response during laryngoscopy and endotracheal intubation.