OBJECTIVE: Purpose of the research was to find out a significant correlation between work related musculoskeletal problems and ergonomic risk factor at workplace setting as well as to compare the ergonomics setting between Indian and American IT companies. METHOD: Pearson correlation coefficient was used to find the relationship between work related musculoskeletal problems and workplace ergonomics risk factors. Musculoskeletal problems have been assessed by using Standard Nordic Questionnaire (SNQ) and ergonomics risk factors by Rapid Office Strain Assessment scale (ROSA). RESULT: 120 participants were assessed with their ergonomic settings using ROSA for IT workers in India and USA in which only 23.33% out of 60 people working in USA depicted higher risk (with score 5 and above) however in India 80% people were at higher risk ergonomic setting. The grand total ROSA score between Indian and American IT professionals companies also showed a significant difference in mean value from being as low as of 4.12±1.03 in American IT companies and in Indian IT companies being a higher value of 5.43±1.29. CONCLUSION: The results of the current study confirmed some of these relationships wherein ergonomics setting affect the occurrence of certain musculoskeletal discomfort. The office workers participating in this research in India were found to have a high level of both MSDs and ergonomic risks. These findings can be further used to guide MSD prevention efforts for office workers in India.