AIMS AND OBJECTIVES: To evaluate various biochemical parameters in cases comprising pre–eclampsia and eclampsia and to compare the results with control group , endothelial and histiocyte markers[CD31,CD34]. MATERIALS AND METHODS The study was conducted in the departments of Biochemistry and pathology,government Medical College and General Hospital, suryapet. 44 subjects of pre–eclampsia and eclampsia patients in third trimester were selected as cases and 44 age and gestational age matched normal antenatal women served as controls,kidney biopsy was done Ihc was done for CD31,CD34. OBSERVATIONS AND RESULTS Total 44 primi cases of pre–eclampsia and eclampsia in their third trimester were selected, out of which 24 cases were pre–eclamptic and 20 cases were eclamptic . 44 healthy primi age and gestational matched subjects were selected as controls.CD31 and CD 34 were shown positive in endothelial cells and histiocytes in kidney biopsy. CONCLUSIONS Serum malondialdehyde levels are significantly increased in the pre eclampsia and eclampsia patients,Serum glutathione s transferse levels are significantly decreased in pre–eclampsia and eclampsia cases, Serum magnesium levels are also significantly increased in cases, Serum uric acid levels are increased significantly in cases, Urine protein per day was significantly elevated in total cases when compared to healthy controls.