Background: Medical therapy in concurrence with conservative approach is the current advance in treatment of ureteric stones which negates the adverse effect of invasive approaches. Tamsulosin and Alfuzosin are two important modalities used in medical expulsive therapy (MET). Methodology: 100 patients were categorized into 2 groups in a 1:1 ratio where Group A Patients were given Alfuzosin 10 mg/day and Group B Patients were given Tamsulosin 0.4 mg/day. Analgesics 100 mg SR tablets were given on demand. Results: Mean age group of the patient were in Group A was 25.4 years (range between 18–41 years) and in Group B was 26.8 years (range between 18– 45 years). Male:female ratio in GroupA and Group Bwas found to be 1.6:1 and 1.5:1 respectively. Right side:Left side ratio in Alfuzosin (Group A) and Tamsulosin (Group B) was found to be 1.6:1 and 1.08:1 respectively. Mean calculus size was 6.7± 1.5 mm in Alfuzosin group and 6.34± 1.7mm in Tamsulosin.. Patients had a mean colicky pain for about 1.7 days before presentation, duration ranged in between (1–5 days). In Alfuzosin (Group A) patients 37/50 (74%) of patient’s calculi found to be expelled and 13/50 (26%) patients required interventions. In Tamsulosin (GroupB) Patients 36/50 (72%) of calculus found to be expelled and 14/50 (28%) patients required interventions. No significant difference between groups with regards to expulsion of stones. Conclusion: The use of Tamsulosin or Alfuzosin as medical expulsive therapy for ureteric stones in distal ureter was effective, as shown by the increased overall stone expulsion rate, reduced stone expulsion time and fewer pain episodes.