Chronic corpulmonale is a serious protracted disease, consuming frequently a large segment of sufferer’s life and quiet often resulting in fatal human experience. Chronic Corpulmonale is traditionally defined as Right ventricular failure secondary to disorders that effect either the structure or function of lungs. It is only recently that clinical physiologists have worked out physiological relationships between chronic pulmonary disease and corpulmonale and still more recently that adequate methods of diagnosis have been established. Chronic corpulmonale can be diagnosed clinically, radiologically, electro cardiographically, by echocardiography, by invasive techniques and more importantly by combination of these methods. Methodology: 50 patients of chronic corpulmonale attending Alluri Sitarama Raju academy of medical sciences, Eluru, Department of Pulmonology who fulfilled the inclusion criteria of the study between December 2015 to June 2017 were taken into this analytical cross sectional study. Detailed history and clinical examination findings were recorded and a battery of investigations –12 lead ECG, x–ray chest,2D Echo cardiogram was done. In selected patients a HRCT chest was done to assess the type and extent of pulmonary lesion. The clinical profile along with the probable etiology, radiological, electrocardiographic and echo cardiographic findings were summarized and compared between different variables. Results: The age of the patient ranges from 35 –80years.The peak incidence was in the fifth and sixth decade, with male and female ratio 80:20 respectively. 76% of male patients were smokers–smoking more than 10 cigarettes/beedies per day. All the patients with cor pulmonale had cough and breathlessness with loss of appetite in 74%. 54% of patients showed radiological signs of chronic bronchitis, only 18% of patients showed gross fibrosis,10%of patients showed normal chest–x– ray. 54% of patients showed right axis deviation on ECG,28% of patients showed P Pulmonale. 33% of patients showed RVSP(right ventricular systolic pressure) more than or equal to 40mmhg and 16% of patients showed paradoxical inter ventricular septum movement. CONCLUSION: chronic corpulmonale was predominantly a disease of middle and older age groups with a peak incidence in the 5th and 6th decades of life. Smoking plays a significant role in participating and aggravating primary lung disease resulting in cor pulmonale. Chronic bronchitis ,COPD, sequelae of pulmonary tuberculosis ,bilateral bronchiectasis were found to be of major causating relationship to corpulmonale. Thorough clinical examination, chest–x–ray ,ECG and echo cardiogram were major contributors to aid in the diagnosis of cor pulmonale.