Introduction: During perimenopause, shifts in hormone levels, can affect ovulation and cause changes in the menstrual cycle. Most of the women especially in developing countries are unaware of these post menopausal consequences, local health authorities have to prepare and plan remedial measures and also should aid in creating awareness among such regions. Materials and Methods: A total of 168 women in perimenopausal period were randomly selected from different areas in this hospital, for example, patient attenders – waiting rooms, screening rooms in different clinics. A Predesigned questionnaire pertaining to socio–demographic characteristics, personal history and 29 item questionnaire adopted from MENQOL. Studied population advised to answer questionnaire. Presence of menopausal symptoms was assessed by scale 0 to 6 depending on how bothersome it is. Point scale zero signifies not bothering some and six signifies extremely bothersome. Results: Majority of the women presented with physical symptoms followed by psychological symptoms. Less prevalence of Vasomotor and sexual domains of MENQOL are observed. Women with normal weight had a high quality of score when compared with overweight or obese. Physically active women with a good life style were showed better QOL score than women exercising <3times/week. The mean QOL score of >5times/week exercise vs 3–5 times/week was 1.7±1.26 and 2.5±1.34 (0.004), >5times/week vs <3 times/week was 1.7±1.26 and 4.8±1.73 (<0.0001). Conclusion: If a woman in perimenopausal transition period focuses on healthy lifestyle including balanced diet, physical activity, meditation etc., then there can be increase in chances of leading a good quality of life.