With increase in life expectancy, nowadays elderly persons cater a large percentage of population. Anemia is present in 10% of women and 11% of men over the age of 65, increasing to 20% of women and 26% of men over 85 .1 Aims: To study and compare the anemia profile between elderly male and female patients aged between 51–80 years & to study the possible etiological profile. Material and Methods: In this retrospective cross sectional study we studied the investigation reports of 100 female and 143 male patients between 51–80 years age with anemia. Results: No significant differences were found between levels of haemoglobin, serum iron and transferrin saturation index (TSI) in elderly male and female. In 51–80 years age group, both female and male patients mostly have moderate anemia . In female anemic patients between 51–80 years, about 19.00% had iron deficiency anemia (IDA), 11.00%, had anemia due to chronic kidney disease(CKD), 9.00% had anemia due to inflammatory causes(INF),13.00 % had malignancy (CA) and 48.00 % patients had anemia due to other causes (OTH). In male,the percentage of IDA,CKD,INF,CA and OTH is 16.90% , 25.35% , 9.15 % , 11.27 % and 37.32% respectively. Conclusion: Early investigations in elderly anemic patients may have implications in reducing morbidity and mortality to a significant extent