Handgrip strength is an important test to evaluate physical fitness and nutritional status. It varies with age, gender, body size etc. This study was carried out in a Medical College of South Bengal to assess gender differences in handgrip strength and to correlate between various anthropometric parameters and handgrip strength in young males & females. The study included 100 apparently healthy medical students (50 male & 50 female) in the age group 17–20 years. Anthropometric parameters like BMI, forearm circumference and hand circumference were measured. Handgrip strength of both hands was measured using a handgrip dynamometer. Results revealed males have significantly greater handgrip strength than females. A positive correlation was found between all anthropometric data with maximum grip strength (MGS) in both sexes except forearm circumference of left hand in females. Strongest correlation of Maximum Grip Strength was observed with hand circumference in both sexes. Thus MGS can be predicted using hand circumference alone.