The present study aims to assess perceived family support and resilience among caregivers of patients with mental illness. The theoretical framework of the present study has utilized certain concepts from Roy’s adaptation theory. The objectives of the study were to assess the perceived family support and resilience, relationship between perceived family support and resilience and the association of perceived family support and resilience with selected demographic variables of caregivers of patients with mental illness. The research approach was quantitative approach with nonexperimental descriptive survey design. Study conducted at a selected psychiatric care setting, Kozhikode. The sample were selected through convenient sampling. The data collection tools were socio demographic proforma, perceived family support scale and resilience scale. The data collected was+ analysed using descriptive and inferential statistics with the application of SPSS Version 16. The findings of the study with regard to perceived family support were low, moderate and high with 7%, 89% and 4% respectively. The data collected on resilience revealed that 0.5% had low resilience whereas 3.5% had mild resilience, 78.5% had moderate resilience and 17.5% had high resilience, among 200 caregivers of patients with mental illness. The result revealed that there is significant correlation between perceived family support and resilience. The findings infer that there is a significant association between perceived family support and history of mental illness (χ2= 20.44, p=0.002) , between resilience and family income (χ2 =20.02, p=0.003), history of mental illness in the family (χ2 =24.97, p=0.003) and duration of mental illness (χ2 =20.37, p=0.0