Introduction: Schizophrenia is one of the world’s most debilitating illnesses with patients experiencing deficits in variety of everyday functional domains (i.e., social, vocational, and independent living). Tobacco use contributes to serious impacts among people with schizophrenia, including increased rates of mortality and morbidity, increased risk of cardiovascular disease, reduced treatment effectiveness, greater financial hardship .Both of them are responsible for the huge indirect costs of schizophrenia, which is up to three times larger than direct treatment costs for psychotic symptoms. Objectives: To evaluate the degree of disability and its relationship with tobacco–dependence. Materials and Methods: A total of 318 Schizophrenic with minimum illness duration of 2 years were assessed for their disability and nicotine dependence using the Indian Disability Evaluation Assessment Scale (IDEAS) and the Fagerström Test for Nicotine Dependence (FTND) respectively. Results: Higher degree of disability is seen in tobacco–users compared to the non–users (mean IDEASG 6.86>5.98, p=0.009). A greater number of tobacco–users had moderate disability (25.8%), majority of which have moderate nicotine dependence (smokers 27%, chewers 44.4%). Nevertheless, severely disabled patients had high nicotine dependence in both smokers (3%) and chewers (4.9%). Conclusion: Present study revealed that the use of tobacco products in schizophrenic is frequently associated with dependence. Mental health providers need to help patients with preventive and rehabilitative actions in the therapeutic plan of each such patient. These interventions should be focused on making the client and the primary care giver ready for bio–psychosocial treatment modality.