Objective: To evaluate the role of Nigella sativa in renoprotection

Material and Methods: This prospective, comparative study was completed in a tertiary care centre of north India in patients of Chronic Kidney Disease (CKD). Group I (Control) received conservative management of CKD and while Group II (Test) received conservative management along with Nigella sativa oil (2.5 mL, orally, once daily) for 12 weeks. Renal function tests were done at 0, 6 and 12 weeks of treatment.

Results: There was more progressive improvement in biochemical values and clinical signs and symptoms in test group. There was decrement in blood urea, serum creatinine and 24–hour total urine protein (TUP). There was rise in glomerular filtration rate (GFR) and 24–hour total urine volume (TUV).

Conclusion: Nigella sativa oil supplementation is effective and safe in prevention of progression of nephropathy.