Oral submucous fibrosis is a chronic precancerous condition that affects the oral mucosa leading to stiffness and causes trismus and inability to eat. This is a most common condition seen in young adults abusing oral betel nut and tobacco chewing, mostly prevalent in India and Southeast Asia. Variety of treatment modalities, conservative and surgical, have been tried with no definitive successful outcomes. In recent times, many ayurvedic preparations have been advocated along with conventional conservative treatment modalities. The present study evaluated the efficacy of tulsi and curcumin in management of oral submucous fibrosis when used along with conventional oral antioxidant therapy.