The effect of vitamin E in thiol status and oxalate binding activity was studied in urolithic patients. Oxalate binding activity and calcium oxalate crystal deposition were markedly pronounced in stone patients. The oxalate binding activities of the COM binding proteins were assayed in all three fractions(F I and F II – pH 7.4; F III – pH 4.5). All the three fractions had oxalate binding activity when compared to control. Fraction I isolated from kidney stone formers exhibited 78.35% increase in with oxalate binding activity [p<0.001] .Vitamin E supplementation to renal stone formers for a follow up peroid of 9 months normalised the thiol status and oxalate binding activities of the COM binding proteins.