We have done a prospective observational study using FNAC, follwed by histopathology and immunohistochemistry of the representative tissue from the specimen of excised thyroid gland. Total 50 number of patient who have undergone thyroidectomy were examined and particularly Ki–67 and p53 immunostaining helped a lot in differentiating benign from maignant follicular neoplasm and thus helped in definitive management of thyroid neoplasms.