OBJECTIVES: To determine the efficacy of U–MDT regimen with regard to relapse rate and acceptability of the patients in pauci and multi bacillary cases. METHODS: 106 leprosy patients aged between 14–60 years attending department of Dermatology, Venerology and Leprosy at RIMS, RANCHI between May 2011 and October 2012 were included in the study and they were allocated U–MDT . Patients were followed up for 12 to 18 months for periodic clinical, bacteriological and histopathological assessment. RESULTS: In histopathological assessment of PB cases, after 6, 12 and 18 months, UPB group showed 91%, 100% and 100% improvement . Among multi bacillary cases, after 12 months 32% of UMB group of patients became smear negative. In histopathological assessment after 12 months, in UMB group, 94% patients showed good improvement. CONLUSIONS: In conclusion, U–MDT was observed to be an effective and useful regimen to treat PB and MB patients of leprosy