Thyroid disorders are known to influence lipid metabolism. Overt and subclinical hypothyroidisms have an adverse effect on the serum lipid profile that may predispose to the development of atherosclerotic disease. In this comparative study, serums of 150 Subjects (50–OH, 50–SCH and 50–Controls) were analysed for Thyroid Profile and Lipid Profile. A significant increase in TC, TG, HDL–C, VLDL–C and LDL–C concentrations were found in OH and SCH than Controls (‘p’= 0.000) except HDL–C level which was not significantly increased in SCH (‘p’=0.110). In OH highly significant Positive correlations were seen between TSH levels and serum lipids concentrations (‘p’= 0.000). In SCH, TSH levels were also in Positive correlation with TC, TG, VLDL–C and LDL–C (‘p’= <0.05) but the correlation was not significant with HDL–C (‘p’= <0.477). This shows that higher the TSH levels, higher will be serum lipids levels.