Surgery over lower limb in patients associated with co morbidities of respiratory and / or cardiovascular system pose high risk for perioperative complications , where change in vital parameters due to anesthesia may be detrimental with patient’s safety. A clinical comparison was made to find a safer technique of anesthesia in such cases undergoing surgery. Methods: A prospective study was carried over total eighty patients associated with co morbidities which were medically treated preoperatively to optimise for anesthesia . Two groups of forty patients each were made and patients were randomly allocated to one of two groups , Epidural block (Group E) was compared with peripheral nerve blocks of lower limb given by nerve stimulator ( Group P ) and quality of anesthesia along with stability of vital parameters studied . Statistical analysis was done using Analysis of variance and student’s t test . Results : the demography was comparable , duration of anesthesia effect was more in patients with peripheral nerve block . group E – 152.8 ± 94 min , Group P– 295.5 ± 26 min ( P < 0.001 ), changes in vital parameters were more frequent in patients given Epidural . Quality of nerve block was good using nerve stimulator , post operative analgesia was additional advantage in cases given nerve block .. Conclusion: Surgery of lower limbs under peripheral nerve block , given with the help of nerve stimulator is a safe and effective technique , it has additional advantage of post operative analgesia .