Leptospirosis is a spirochetal bacterial infection and causes clinical illness in animals and humans. This disease is predominantly seen in farmers, trappers, veterinarians, and rice–field workers. Leptospirosis mainly affects liver and kidney. Rarely, other organs such as lung, heart, gallbladder, brain, and ophthalmic tissues are involved, mainly due to vasculitis . It can rarely present as acute pancreatitis. Hyperamylasemia can be present in leptospirosis infection due to renal impairment. So, the diagnosis of acute pancreatitis is controversial in this disease. Therefore we have presented a rare case of pancreatitis in a patient of leptospirosis in our hospital, AMCH,Dibrugarh