IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-8-7-19970 Original Research Paper Prospective Study of Juvenile Nasopharyngeal Angiofibroma Ashish Keche Dr. Dr Seema Patel Dr. July 2019 8 7 01 02 ABSTRACT

Aims and Objectives: To study the role of various diagnostic modalities and to analyze the efficacy of pre operative embolisation in management of angiofibroma; lastly to evaluate the role of hormonal factors in pathogenesis of angiofibroma. Material and Method: In present study, 31 patients diagnosed clinically and radiologically as a case of Juvenile Nasopharyngeal Angiofibroma. After diagnosis they were subjected for angiography and pre operative embolisation of feeding vessels. Usually after 20–40 emboli were introduced check angiography was done. Patients were treated surgically using various surgical approaches. After surgery, total intraoperative blood loss was calculated. In all patients serum testosterone assay was done using Elisa method. Results: The mean age of the patient was found to be 17.8 years. The preoperative diagnosis was done by clinical findings and CT findings and the patient was staged accordingly. We found that internal maxillary artery was the most common feeder in all the cases. 26 patients underwent temporary embolisation using gel foam and 5 patients underwent permanent embolisation using PVA particles. Blood loss was not so severe, only one patient had blood loss around 2350 ml. Serum testosterone was found raised in one patient and normal in 30 patients. Conclusion: Juvenile Nasopharyngeal Angiofibroma was clinically diagnosed and should be managed by surgery, without much bleeding intraoperatively due to preoperative embolisation and minimal recurrence and there seems to be a role of androgen in pathogenesis of angiofibroma