There are two types of functions of vitamin D. First one is skeletal and second one is non skeletal.Skeletal functions of Vit. D are mainly invovlved with the calcium metabolism and effector organs are kidney, gut and bone.Non– skeletal functions are evolutionarily more primitive but their importance has been realised very recently.Besides calcium metabolism Vit D is extensively studied for its beneficial effects on heart, diabetes , psoriasis,asthma etc. The purpose of this study is to show whether Vit.D supplementation among diagnosed cases of Rheumatoid arthritis(RA)have any anti–inflammatory effect or not.For this purpose two inflammatory markers interleukin–1β (IL–1β) and Tumour necrosis ffactor–α( TNF–α) were estimated before and two months after supplementation of Vitamin D. The serum levels of both IL–1β anTNF–α were significantly lower after two months of Vitamin D supplementation (p<.005 for both IL–1β anTNF–α), indicating anti–inflammatory,systemic benefit of vitamin D supplementation.