Smoking causes coronary heart disease, abdominal aortic aneurysm; lung, mouth and throat cancer, nerve and blood vessel damage. Hence the present study was undertaken to observe the effect of cigarette smoking on Serum lipid Profile and Fasting Blood Sugar level. A cross sectional study involving 100 Non–Smokers healthy individuals and 100 Smokers of same age group was planned. Result of the present study shows significantly higher value of fasting blood sugar, serum Cholesterol, Triglyceride and Very Low density lipoprotein with significant lower value of serum High density lipoprotein in smokers as compared to non smokers. This study concluded that, cigarette smoking induces dyslipidaemia and increase fasting blood sugar level in the direction of increased risk for coronary artery disease. So it is strongly recommended to avoid smoking for the benefit of cardiac health