Alzheimer’s Disease is a progressive illness ,causing memory loss and cognitive decline in several domains.Commonly occurs at the age above60.Patients eventually die from complications like infection,dehydration and malnutrition.Current medications like cholinesterase inhibitors may slowthe progression but unfortunately there has been no curative treatment till now.So there is an urgent need to develop new promising treatment approaches.Following review is regarding the Alzheimer’s disease and its therapies that are under research and reasons for the unsuccessful clinical trials