Background: With the rising incidence of blunt trauma abdomen, gastro–intestinal malignancies, mesenteric thrombosis, bowel strangulation etc., there is an ever–increasing need for resection anastomosis to correct these surgical conditions. This prospective comparative study is performed to evaluate the safety and effectiveness of single layer interrupted extramucosal technique as compared to conventional double layer technique in term of anastomotic leak and other complications. Methods: The patients selected for this study are those who were admitted with various clinical conditions requiring resection and anastomosis of small or large bowel presented to Krishna Hospital and Medical Research Centre, Karad during June 2018 to May 2019. A total of 50 patients were included in the study. A total of 50 patients were included in this study. Subjects over 18 years and below 60 years were included in this study and effectiveness of single layer bowel anastomosis was compared to traditional two layer anastomosis. Results: Though a large number of patients need be to studied to do a dogmatic conclusion, based on the results obtained in the present study following conclusions can be drawn. Duration required to perform a single layer intestinal anastomosis is significantly lesser when compared to double layer. There is no significant difference in anastomotic leak between two groups. There is no significant difference in duration of hospital stay in single vs double layered bowel anastomosis. Conclusions: Single layer interrupted extra–mucosal technique required significantly less duration for anastomosis, is cost effective with no significant difference in anastomotic leak rate and as safe as conventional double layer technique.