Introduction: Hospital infection control is seeing a paradigm shift in the current times and microbes know no borders. Health care associated infections(HAIs) have become a major concern with complex surgeries, prolonged hospital stays and rampant misuse of antibiotics. There is a need to implement and follow standard guidelines as suggested by National Accreditation Board for Hospitals and Healthcare Providers known(NABH) which is committed to support improvement of quality of healthcare service in our country for all strata of the population through various methodologies and tools to supplement the efforts of the providers of healthcare service. Materials and Methods: We describe a prospective study between January–June 2018 for implementing the NABH guidelines for implementing hospital infection control standards in our hospital to document, monitor and reduce HAIs in our setting. We also discuss the need for the same, the pros and cons in the process of implementation. Results: Key Quality Indicators were defined and monitored with definitions, checklists and trend analysis using Plan–Do–Check–Act (PDCA) cycle. Conclusion: Our study helped us identify modifiable challenges to infection control practices within hospitals based on recommended guidelines. Infection control and prevention of HAIs is a continual process and is a critical component of all specialties of healthcare services, therefore requires more attention from hospital administration.