Background and aim:– Laryngoscopy and endotracheal intubation violate the Patient’s protective airway reflexes and invariably cause hemodynamic changes associated with increased heart rate, increased blood pressure and occasional disturbance in cardiac rhythm. These hemodynamic changes arise as a form of sympathoadrenal reflex. The present study compared the efficacy of pregabalin and gabapentin for attenuation of sympathomimetic response to laryngoscopy and intubation. Materials and Method:– Randomly selected 90 patients in between the age of 20–50 years with ASA grade I or II posted for elective surgical procedure under general anesthesia were randomly allocated in 3 groups(n=30). Group P (pregabalin group)–received 150mg pregabalin 1 hour prior to surgery and Group G (gabapentin)–received 900mg gabapentin 1 hour prior to surgery. Group C (control)–received vitamin B–complex capsule 1 hour prior to surgery. Hemodynamic parameters like heart rate (HR), systolic and diastolic blood pressure, mean arterial pressure (MAP) were recorded at baseline, during intubation and 1, 3, 5, 10, 15, 20, 25 and 30 minutes after intubation. Results:– Pregabalin 150mg attenuated hemodynamic stress response in terms of Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure and Rate Pressure Product better than Gabapentin 900mg during laryngoscopy and endotracheal intubation. Both were effective in attenuating hemodynamic response as compared to placebo. Drowsiness was the only side effect seen in few patients. But the adverse effects did not cause any harm to the patient and corrected spontaneously. Conclusion: – Both Pregabalin and Gabapentin attenuated the hemodynamic responses to laryngoscopy and intubation. Pregabalin was more effective with minimal adverse effects