Objectives: Synovial membrane biopsy is of great importance in the assessment of joint diseases synonial conditions & it is the final tool for diagnosis. The present study was mainly to assess the incidence of various joint diseases and diagnosis the joint diseases by histopathological and so clinical parameters and to correlate the clinical findings with histopathological study to minimize the number of non specific synovitis. Materials and Methods: The present study was carried on a total of 15 patients, Whose knee joint was involved at tertiary care Hospital research center Surat between September 2015 to March 2018, by open and arthroscopic biopsy. Results: Most of the cases were diagnosed as chronic non specific synovitis (6), followed by tubercular synovitis (2), septic arthritis (1), Rheumatoid arthritis (1), Gouty arthritis (1) osteoarthritis (1), synovial osteochondroma (1), GCT of tendonsheath (1), & synovial sarcoma (1). Those histopathological features which were not specific of any disease in 6 patients were labelled as nonspecific synovitis; Definitive histological diagnosis was given in remaining cases. The concordance between clinical, histopathological diagnosis was 60% and discordance between the two was 40%. Conclusions: From the results of present study after comparison with study of synovial membrane in various other series. It is evident that synovial biopsy is an important adjuvant together with clinical details for giving a definitive histopathological diagnosis