Background : Schizophrenia is a severe mental illness, resulting in impairing and debilitating worldwide. The primary care giver is expected to meet all the deficiencies of the sick relative leading to reduction in their QOL. So the present study aims to study QOL and factors influencing them, so as to facilitate better prognosis and to improve their QOL. Aim : To study the caregiver quality of life in the spouses of patients with schizophrenia. Objectives: 1. To study the quality of life in the spouses of patients with schizophrenia. 2. To study the factors influencing the caregiver quality of life. Methodology : A consecutive sample of spouses of 100 patients with schizophrenia were taken at IMH, hyderabad. A semi structured questionnaire was administered to collect the socio demographic details. Followed by IDEAS for measuring and quantifying the mental illness, WHO –QOL BREF to assess the quality of the life respectively. Statistical analysis was done using SPSS. Results : Mean quality of life in four different domains are : 44.9±15.9 in physical health, 36.2±15.0 in psychological health domain, 37.9±16.8 in social health domain and 37.3±14.4 in environmental health domain . Better QOL is seen in younger age group, post graduates, male gender, urban, extended family, homemakers, who are financially not dependent on the patient, with monthly income > 10,000, who are having no mental illness, no substance abuse and no physical abuse by the patient. Of which age appears to be statistically significant in physical and social domains. The factors like type of schizophrenia and severity of illness strongly associated QOL. Conclusions: Better QOL is seen in physical health domain and in socio demographic details younger age is found to be significantly associated with better QOL than other details. Psycho– therapeutic techniques like psycho education, family and couple therapy may help in better coping of spouses of mentally ill persons. Group therapy can help spouses in sharing their views and understanding various coping methods employed by others