Aim: To study clinical and epidemiological parameters of patients undergoing percutaneous coronary intervention (PCI) with severe left ventricular dysfunction (LVD) and to follow them up for understanding outcomes of procedure. Materials & methods: This is retrospective data analysis of 157 patients who underwent PCI from January 2016 to November 2017 at the department of cardiology in our institute and were followed up at July 2018. Patients who were in cardiogenic shock or required vasopressors or support ventilation before or at the time of PCI were excluded from the study. Epidemiological variables considered were age, gender, diabetes, hypertension, smoking, alcohol intake & tobacco chewing. Clinical parameters taken into account were Left ventricular ejection fraction (LVEF), ST elevation myocardial infarction (STEMI) or non ST elevation myocardial infarction (NSTE–ACS) or chronic stable angina (CSA), thrombolysed or not. Angiographic data considered were chronic total occlusion (CTO), single vessel disease (SVD) or double vessel disease (DVD) or triple vessel disease (TVD) and stent dimensions. Follow–up was done to report incidence of local site complications, stent thrombosis, in–stent restenosis, NYHA class and death. Results: Out of 157 patients, 113 (71.97%) were male & 45 (28.66%) were female, with both median age and mean age being 56. 51 (32.48%) were diabetic, 52 (33.12%) were hypertensive, 22 (14.01%) patients were tobacco chewer, 42 (26.75%) were smokers & 30 (19.10%) were alcoholic. 151 (96.17%) patients had STEMI, 6 (3.82%) had NSTE–ACS, 1 had CSA. 60 patients were thrombolysed (38.21%) before being referred to our centre. AWMI was diagnosed in 145 (92.35%) patients & IWMI in 11 (7%) patients. 14 (8.91%) patients were CTO, out which only one attempt of PCI failed. 113 (71.97%) were SVD, 40 (25.47%) were DVD & 5 (3.18%) were TVD. 146 (92.99%) patients had LAD involvement and among DVD patients, LAD & RCA were most commonly involved in 22 (55%) patients. LAD PCI was done with average stent diameter of 2.96 mm & length of 26.8 mm, LCX PCI was done with average stent diameter of 2.25 mm & length of 30 mm and RCA PCI was done with average stent diameter of 3.32 mm & length of 27 mm. On follow–up of mean 604.42 days (minimum 268 days, maximum 909 days), no episodes of subacute stent thrombosis or ISR occurred and no mortality was reported. Majority of patients belonged to class III NYHA pre PCI 92 (58.59%), while post PCI majority of patients were in NYHA class II 82 (52.29%). Summary: As per our knowledge this is the first study to report data of PCI in severe LVD from Indian subcontinent. The study shows affection of young male population predominately. SVD is the most common angiographic diagnosis with LAD predominately affected vessel. This real world–data on clopidogrel with aspirin as dual anti–platelet therapy and second generation stent in patients with severe LVD shows no episode of stent thrombosis or ISR and significant improvement in NYHA class. Condensed Abstract: 1. The data of PCI in severe LVD from Asian subcontinent is lacking. No study could be searched at the time of writing manuscript in either PubMed or Google Scholar on this topic from Indian origin except for the data for CABG in severe LVD. Hence, it is the need of hour to collect data regarding outcomes of PCI with severe LVD. This study, though observational becomes pioneer for this context. 2. This registry being real–world scenario has shown very promising outcomes of PCI despite use of second–generation stents and clopidogrel as a second antiplatelet in combination to aspirin. 3. As per our knowledge this is the first study to report data of PCI in severe LVD from Indian subcontinent. Limitation: Due to non–invasive follow–up, exact amount of stent restenosis can not be calculated. Impact on daily practice: This real world–data on clopidogrel with aspirin as dual anti–platelet therapy and second generation stent shows negligible event of stent thrombosis & ISR even in patients with severe LV dysfunction. This can help reduce cost burden on society and help better distribution of health budget.