Background: Stroke serves as the leading cause of death and physical disability. This study was conducted to find the relationship between platelet indices and severity of acute ischemic stroke. Materials and methods: This was a cross–sectional study conducted among 60 ischemic stroke patients divided into severe and mild stroke based on modified Ranking Score(mRS) with 30 patients in each group and 30 normal individuals. Platelet indices(Platelet count and Mean Platelet Volume) were obtained from CBC report. Results:There was a significant decrease in platelet count and increase in Mean Platelet Volume(MPV) in stroke patients when compared with normal persons and also in severe stroke patients when compared with mild stroke patients with p values 0.001 and < 0.001 respectively in both comparisons. Conclusion: Patients with severe stroke had lowest platelet count and the highest MPV in our study.There is a positive association between platelet indices and the severity of acute ischemic stroke. Platelet indices can serve as an important predictor for the prognosis of acute ischemic stroke. It also helps in risk stratification in ischemic stroke patients so that they can be given more vigilant and aggressive care that can lead to decrease in morbidity and mortality.