Peripheral arterial disease (PAD) is most common among the men, especially chronic smokers and incidence in India is 1 in 5000 men. Multiple modalities of treatment available for the disease but many of them are expensive and cannot be performed in many patients due to various reasons. So our study assesses the association of testosterone to PAD and its use as a therapeutic drug. Testosterone causes vasodilation of the peripheral arteries by acting on the endothelium of the vessels and in turn results in release of nitric oxide (NO) which is a vasodilator and helps in vasodilatation of the vessels.1–2 The current study is being done to investigate a possible link between serum testosterone and lower extremity PAD in men and to know whether Short–term administration of testosterone induces a beneficial effect in men with peripheral artery disease. This effect may be related to direct peripheral artery–relaxing effects.