The aim of the study was to investigate the role of transabdominal ultrasonography (TAS) and endoscopic ultrasonography (EUS) in diagnosis of chronic pancreatitis (CP). The objectives of our study were to assess the advantages and disadvantages of TAS and EUS in diagnosis of chronic pancreatitis and further evaluate the effectiveness of TAS and EUS in grading severity of CP. We included 30 clinically suspected patients of CP. All patients were initially evaluated by TAS followed by EUS. EUS was found to be more sensitive in detection of calcification (80% v/s 46.7%), heterogeneity (100% v/s 87%) and intraductal calculi (69% v/s 66%) as compared to TAS while TAS was more sensitive than EUS in detection of ductal dilatation (80% v/s 69%). TAS is considered as first imaging modality in evaluating patients of CP while EUS can be helpful in early diagnosis and prognostication of CP.