Toothpaste aids in removing dental plaque and food from the teeth, assists in suppressing halitosis, help prevent tooth decay (dental caries) and gum disease (gingivitis) , to promote oral hygiene. Multiple toothpastes have become available, which contain all the ingredients that would take care over gingivitis, tartar control sand whitening of teeth. Tooth whitening is an important criteria for many of us. Toothpaste remove plague, stains for which whitening abrasive particles on the toothpaste plays an important role. Currently the advances in the ingredients and additives to toothpastes offers some good clinical choices. In the present study ten different marketed brands of toothpastes were evaluated for various parameters like appearance, pH, spreadabiity, homogeneity, moisture content, heavy metals, anti–microbial activity and the results are in compliance with the standards of BIS. Lastly all the brands of toothpastes taken for the study possess anti–microbial activity, the better activity was seen in Sensocheck–F and Enshine when compared with the other brands, Sensocheck–F being a medicated toothpaste and it possess good anti–microbial effect to maintain oral hygiene.Even the herbal toothpastes like Vedshakti and Himalaya also have anti–microbial activity but it was less compared to medicated toothpastes.