IJSR International Journal of Scientific Research 2277 - 8179 Indian Society for Health and Advanced Research ijsr-8-9-21895 Original Research Paper A single centre Case series study of Clinico-pathological Spectrum of Primary Ovarian Malignant Mixed Mullerian Tumours DHANESH KUMAR Dr. September 2019 8 9 01 02 ABSTRACT

Aims and Objectives: To study the clinical and pathological characteristics of primary ovarian malignant mixed mullerian tumor (OMMMT) and assess the prognostic factors associated with treatment outcome and survival. Materials and methods: The pathology database was searched for primary ovarian carcinosarcoma diagnosed or managed at our institute from period of february 2014 to June 2019. The histological sections were reviewed, with emphasis on type and grade of epithelial and sarcomatous component. The medical records were retrospectively analyzed for clinical details and follow up. Results: A total of 35 cases of primary ovarian carcinosarcoma were identified. The median age at diagnosis was 49 years. Sixteen patients had advanced stage (stage III and IV) at presentation. Cytoreductive surgery was done in 17 cases, and 9 had received upfront chemotherapy.Histologically, 12 cases had epithelial predominance (> 50% epithelial component) and 13 had sarcoma predominance. The most frequent epithelial component was endometroid type, and most common sarcoma component was rhabdomyosarcomatous. Hyaline droplets within sarcomatous stroma were seen prominently in 16 cases. Three cases showed germ cell or yolk sac–like areas. Twenty cases had follow up with a median of 14 months (4–45 months). The recurrence–free survival in advanced stage and sarcoma predominant was 9.5 months in comparison to 13 months in early stage and epithelial predominant OMMMT. Conclusion: Primary ovarian carcinosarcoma is a rare biphasic malignancy with variable proportions of epithelial and spindle elements. Presence of hyaline droplets within spindle sarcoma in a biopsy from ovarian mass should alert the pathologists regarding MMMT. Advanced stage, suboptimal cytoreduction, and sarcoma predominant tumors are likely to have a worse outcome in ovarian MMMT.