Oral submucous fibrosis is a chronic precancerous condition is a slowly progressive chronic disease of the oral cavity and oropharynx, characterized by fibroelastic change and inflammation of the mucosa leading to progressive inability to open the mouth, swallow or speak. Various antioxidants have been tried to treat OSMF with varying degree of success. The present study conducted is much of a keen interest because there is much new information, about the benefits of antioxidants such as lycopene and spirulina for both prevention and treatment of diseases. Spirulina and Lycopene have anti–inflammatory, anti–oxidant and immuno–modulatory properties are gaining attention due to their decreased adverse effects. Aims: To assess the effectiveness of spirulina and lycopene in the management of oral submucous fibrosis along with intralesional triamcinolone acetonide injection. Methods and Material: This study included 40 Oral submucous fibrosis patients divided into two groups( Group I and II) 20 patients in each group according to Lia DR classification. Group I (n=20): were given spirulina 500 mg capsules in two divided doses daily for 3 months.Group II (n=20): were given Lycopene 10 mg capsules in two divided doses daily for 3 months. Patients in each group were evaluated every month for the three subsequent months for the improvement in reduction in the burning sensation and the mouth opening.The measurements for the burning sensation was recorded using NAS and mouth opening was done by vernier calliper. The measurements at the baseline and after 30,60 and 90 days were compiled and subjected for analysis. Statistical analysis was done for inter–group and intra–group comparison. Results: There was improvement in the mouth opening and reduction in the burning sensation in patients of each Group I and Group II. When intergroups were compared, the difference in the improvement of mouth opening was not significant between Group I and II. Intergroup comparison with respect to reduction in the burning sensation after three months was significant in Groups II as compared to Group I. Conclusions: The study concluded that Lycopene as an adjuvant antioxidant to corticosteroid (triamcinolone acetonide) injection showed significant reduction in the burning sensation compared to Spirulina in patients with oral submucous fibrosis (OSMF). This could be because of the potent anti–inflammatory and antioxidant properties of Lycopene.