An attempt was made to synthesize various flavones. The structures of the compounds were elucidated by UV, IR, 1H–NMR, and mass spectrometry. Furthermore, an –vivo anti–diabetic activity study was carried out. The study reveals that flavones such as F1, F2, F3, F5 and F8 were potentially considered for in–vivo anti–diabetic activity by streptozotocin induced model. Fasting blood glucose and biochemical parameters like total protein, urea, creatinine, SGOT, SALP and SGPT were performed for the biological evaluation and compared with that of standard glibenclamide (5 mg/kg). Among the five consolidated flavones, F8 possess high significant (p < 0.01) results and restores the blood glucose level, liver enzymes and renal parameters. Based on these results, a promising potent drug would be developed in the management of diabetes mellitus.