Paraplegia compromises the life of the individual as well as the family. While the entire family is affected by its occurrence, it is one of its members known as the family caregiver who assumes responsibility for the care of the individual and his needs. The planning, implementation and evaluation of educational intervention for family caregivers regarding appropriate ways to perform care and adaptation to the environment falls under the nurse’s responsibility. The present study focussed on the effectiveness of nursing intervention on practice of family caregivers of patients with paraplegia. The research design adopted in the study was quasi experimental pretest post test control group design and was conducted in physical medicine and rehabilitation wards. The sample consisted of 80 family caregivers who satisfy the inclusion criteria. Nursing intervention consisted of the structured, individual patient and caregiver education of 3 sessions of 45 minutes duration using power point slides on exercises, nutrition, skin care, sexual functioning, psychological aspects, bladder training, bowel training, demonstration and return demonstration of exercises and provision of an information booklet describing the interventions to be followed by the patients and family caregivers. Post test was conducted on 25th day and 90th day. The effect of intervention was found to be significant which indicates that there exists a significant difference in practice scores of family caregivers of patients with paraplegia.