Introduction: Carcinoma cervix is the fifth most common female cancer worldwide as well as in India. Human Papilloma Virus (HPV) is the cause of this cancer in western world whereas there are other causes which are more common in causing this cancer in Indian women. In order to see the association of HPV with Indian cancer cervix patients we conducted a pilot study to see HPV and its common genotype in cancer cervix patients. Material and Methods: We took 52 cancer cervix cases that presented to this hospital and tested by the biopsy tissue for HPV and its genotype by polymerase chain reaction and Restriction Fragment Length Polymorphism respectively along with the histopathological examination. Results: 44 patients of squamous cell carcinoma showed presence of HPV with strains 16 and 18 in 81% cases either alone or together. On history it was seen that most of these patients did not use barrier contraceptive which may protect from viral infection. Conclusion: HPV 16 and 18 are commonly association with squamous cell carcinoma cervix along with other causative factors common in India. More studies are required to establish the prophylactic use of HPV vaccination in Indian girls which may help in preventing cancer cervix in some cases.