Perforation peritonitis is one of the commonest emergency encountered by the surgeons. Surgery for perforation peritonitis is associated with the highest rates of infective complications especially surgical site infections because there is contamination of operative field with micro organisms from endogenous source. AIMS AND OBJECTIVES: Comparison between the subcutaneous suction drain and subcutaneous corrugated rubber drain in prevention of post laparotomy wound infection in patients of perforation peritonitis. To determine advantages and disadvantages of each method with regard to surgical site infection, hospitalization, cost and morbidity. MATERIALS AND METHODS: The present study entails 60 patients having been operated for perforation peritonitis admitted in the Post Graduate Department of Surgery Government Medical College, Jammu over a period of one year (1st November 2017 to 31st October 2018). The study consisted of two groups:– Group A:– In this group, abdominal wall closure was done by suturing of the linea alba with continuous sutures without tension at the suture line with or without interrupted suture at 2 or 3 places with PDS 1 No and the subcutaneous space drained by a negative suction drain. Group B:– In this group after closure of abdominal wall with the same technique a corrugated rubber drain was placed in subcutaneous tissue All patients were studied postoperatively in terms of duration of hospital stay, expenditure, subsequent surgeries, post operative wound infection and wound dehiscence. RESULTS The patients in group A (n=30) in which suction drain was used in subcutaneous space during closure of abdominal wound , the incidence of seroma formation, wound dehiscence requiring secondary suturing and mean hospital stay was significantly lower than the patients in group B (n=30) in which corrugated rubber drain was used in subcutaneous space while closure of the laparotomy wounds in patients presenting with perforation peritonitis (n=60) CONCLUSION: In conclusion, we recommend the usage of negative suction drain over corrugated rubber drain in subcutaneous space during closure of abdominal wound in patients presenting with perforation peritonitis.