Aim: The aim of the study was to evaluate the efficacy of DrOroscope (International patent publication no. WIPO/PCT WO2019/035024 A1) in the early detection of oral potentially malignant and malignant lesions Materials and Methods: From a pool of 1000 patients, 170 subjects with oro–mucosal lesions were subjected to thorough clinical, blue light analysis and the suspicious lesions were subjected to histopathological evaluation. Considering the histopathological inference as a standard parameter, a comparison was made with the result obtained using DrOroscope to evaluate the efficacy of the latter. Results: Of the 170 subjects 28.3% of the sample with lesions sounded dysplastic and the rest fell into pigmented, aphthous & traumatic ulcer’s categories. A comparison amidst the diagnostic efficacy of DrOroscope & histopathological evaluation unveiled a sensitivity of 100% and a specificity of 98.3%. The analyzed data through statistics has put a P value which is much lower than 0.05 reinforcing the efficacy of DrOroscope as the results were in par with histopathological assay. Conclusion: DrOroscope can be used as a clinical diagnostic aid in the detection of potentially malignant and malignant lesions of the oral cavity. Alongside, it also delineates the borders, while a biopsy or surgical excision is instituted.