In female genital tract, an adenofibroma is commonly reported in ovary and rarely in cervix while it is extremely rare in endometrium. Here, we report a case of papillary cystadenofibroma of uterus in a postmenopausal woman with history of breast carcinoma. In our review of published case reports, very few cases have been reported so far arising from endometrium, presenting as polypoidal lesions in uterine cavity. In all reported cases, six patients had history of breast carcinoma. There has been an attempt to establish relationship between adenofibroma of uterus and tamoxifen intake in patients with breast carcinoma. However, our patient did not receive tamoxifen. In a view of reported incidence of these tumours in breast cancer patients we propose a theory that uterine mixed Müllerian tumour may be secondary to yet unknown genetic risk factor independent of tamoxifen.