Background: Laparoscopic cholecystectomy is the gold standard for the treatment of symptomatic gallbladder disease. Laparoscopic cholecystectomy decreases postoperative pain, allows earlier oral intake, shortens hospital stay, and improves cosmesis over open cholecystectomy. Objectives: To evaluate difference between two port laparoscopic cholecystectomy versus four port laparoscopic cholecystectomy regarding intraoperative and post operative complications and morbidity due to sugery (if any). Methods: Patients were diagnosed Gallbladder stones who were posted for surgery were included in our study after taking consent in which around 66 patients were selected. Results: In two port LC, mean age was 35.81 + 16.1 years and in four port LC, mean age was 36.84 + 26.14 years,mean time of surgery of 2 port LC is 62.09+10.6 min and of 4 port LC 57.15+8.2 min,with minimal conversion rate in 2 port LC(1 case) and none in 4LC group,.The mean postoperative pain (vas) at 48 hours, in 2 port LC is 3.75 + 2.0 and in 4 port LC is 4.82 +0.78.Postoperative analgesia (mean) in 2 port LC 169.69+145.64 and in 4 port LC 236.36+97.7. All patients of 2 port LC were mobilized on day 1, whereas 23 patients of 4 port LC were mobilized on day 1 and remaining 10 patients on day 2. Conclusions: 2 port LC resulted in less post operative pain, less post operative requirement of analgesia, with comparable operative time, intra operative complications, when compared to 4 port LC.