The study used a quasi–experimental design (non–equivalent control group pre– test–post– test design). Population comprised 100 adult patients with stage 3 and stage 4 chronic kidney disease patients whose glomerular filtration rate (GFR) was deteriorating and required to undergo haemodialysis treatment. Compliance scale developed by researcher was used to assess patient compliance to therapeutic regimen. After the implementation of pre–haemodialysis preparatory program, highly significant improvement with moderate to large effect size was observed in patients‘ receiving pre–haemodialysis preparatory program with relation to overall compliance to therapeutic regimen( P=.000) as compared to those receiving standard care. After controlling for confounding socio–demographic variables (age (P=0.049) education (P= 0.036), and annual income (P=0.015)) the intervention was found to be significantly effective in improving compliance to therapeutic regimen (P = 0.000).