Objective: To determine drug utilisation pattern in outpatient department in medicine OPD of King George’s Medical University, Lucknow. Material and methods: Study was prospective, observational, and cross–sectional conducted in Outpatient Department (OPD) of medicine. Sample size was 400 according to the World Health Organization manual Study. Data was expressed as, frequency, mean±SD, range and percentage. Result: : After compiling the data, overall review shows average number of drugs as 5 and standard deviation with ± 1.6.Drugs by generic name as 1%. Antibiotics prescribed are 40% and 19% drugs from essential drug list. Counters with injection prescribed are 2%. According to the data, maximum numbers of drugs were greater than four. Maximum percentage of drugs prescribed per prescription is greater than four i.e., 42% and minimum is 1% with zero number of drugs in a prescription in medicine OPD.