The rising rate of cancer is a problem all over the world, including India. Recent research has shown that HIV–infected individuals have elevated rates of several cancers, and that an increasing proportion of these cancers are now non–AIDS related malignancies.HIV–infected individuals have a higher incidence of both virus–related cancers, and tobacco/alcohol–related cancers, due to higher prevalence of HIV–induced inflammation, immunodeficiency, and tobacco use among HIV–infected compared with HIV–uninfected individual. Our study attempted to estimate the prevalence of HIV positivity among patients diagnosed with oral cavity cancers.