Introduction: Severe metastatic or complicated infections are associated with Staphylococcus aureus (S. aureus) bacteraemia. Multidrug resistant (MDR) strains of S. aureus, particularly Methicillin Resistant S. aureus (MRSA) cause hard to treat infections, thus making the first line drugs ineffective. Methodology: Retrospective data was collected from all MRSA bacteraemia events in children (0– 16 years) from Jan 2019 to June 2019 at Bai Jerbai Wadia Hospital, a tertiary care pediatric hospital in Mumbai. Results: The overall prevalence of methicillin resistance during the study period was 79.55 %. The overall prevalence of methicillin resistance during the study period was 79.55 %. No isolates were found to be resistant to Vancomycin, Teicoplanin, Linezolid or Tigecycline. Conclusion: The study showed alarmingly high level of bacteraemia, due to MRSA in the pediatric population. Multiple–non–β–lactam agents have also become ineffective against the newer strains isolated.