Carmozyme, a natural formulated enzyme rich supplement was prepared for dyspepsia, anorexia, gastric ailments, and other GI problems. The present study was design to find out the digestive stimulant actions of Carmozyme on food propulsion, gastric functions and intestinal enzymes secretions in animals. A significant dose dependent (1ml/kg, 2 ml/kg and 3 ml/kg body weight) inhibitory effect on reducing gastric volume, acidity and ulcer index were observed in Carmozyme treated animals with compared to control animals. Carmozyme also enhances the mucin content in gastric juice. Moreover, Carmozyme produced a dose–dependent effect in reducing intestinal motility and gastric emptying time in rats. It also significantly enhanced the enzymatic activities of gastric pepsin and intestinal amylase and lipase. These findings suggest that the use of enzyme rich supplements in treating hyperacidity, indigestion and abdominal discomfort. Thus, it is concluded that Carmozyme improves digestion and reduce digestive ailments